Antimicrobial surfaces for craniofacial implants: state of the art
Lisa Actis, Laura Gaviria, Teja Guda, Joo L. Ong,
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( Lisa Actis ) - University of Texas at San Antonio Department of Biomedical Engineering
( Laura Gaviria ) - University of Texas at San Antonio Department of Biomedical Engineering
( Teja Guda ) - University of Texas at San Antonio Department of Biomedical Engineering
( Joo L. Ong ) - University of Texas at San Antonio Department of Biomedical Engineering
KMID : 0355620130390020043
Abstract
In an attempt to regain function and aesthetics in the craniofacial region, different biomaterials, including titanium, hydroxyapatite, biodegradable polymers and composites, have been widely used as a result of the loss of craniofacial bone. Although these materials presented favorable success rates, osseointegration and antibacterial properties are often hard to achieve. Although bone-implant interactions are highly dependent on the implant’s surface characteristics, infections following traumatic craniofacial injuries are common. As such, poor osseointegration and infections are two of the many causes of implant failure. Further, as increasingly complex dental repairs are attempted, the likelihood of infection in these implants has also been on the rise. For these reasons, the treatment of craniofacial bone defects and dental repairs for long-term success remains a challenge. Various approaches to reduce the rate of infection and improve osseointegration have been investigated. Furthermore, recent and planned tissue engineering developments are aimed at improving the implants’ physical and biological properties by improving their surfaces in order to develop craniofacial bone substitutes that will restore, maintain and improve tissue function. In this review, the commonly used biomaterials for craniofacial bone restoration and dental repair, as well as surface modification techniques, antibacterial surfaces and coatings are discussed.
키워드
Dental implants; Osseointegration; Antimicrobial agents; Surface-coated materials; Bone regeneration
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